Directors: A. . Van Oijen

Prerequisites: The course is intended for all DMS graduate students and is open to advanced undergraduates.  Credits: 4 CREDITS (Non-Clinical Elective)

Offered: Spring.  Time: TBA  Place: TBA

Description: Protein biochemistry with emphasis on the interrelated roles of protein structure, catalytic activity, and macromolecular interactions in biological processes. Both fundamental principles and experimental ...

Directors: D. M. Coen

Prerequisites: Primarily for graduate students.  Credits: 4 CREDITS (Non-Clinical Elective)

Offered: Spring.  Time: TBA  Place: TBA

Description: Application of molecular and structural biology, genetics, genomics, chemistry, and modern enzymology to drug action and development of new therapies. Analyzes molecular underpinnings of pharmacological ...

Directors: J. . Bergman

Credits: 4 CREDITS (Non-Clinical Elective)

Offered: Spring  Time: TBA  Place: TBA

Description: Introduction to CNS pharmacology and behavior in seminar format. Effects of psychomotor stimulants, antischizophrenics, opioid analgesics, and antianxiety agents on behavior. Emphasis on methodology and ...

Directors: G. . Wagner

Prerequisites:   Credits: 4 CREDITS (Non-Clinical Elective)

Offered: Not Offered 2009-2010  Time: TBA  Place: TBA

Description: Theory and practice of modern methods of macromolecular structure determination using multi-dimensional NMR. Note: Given in alternate years. Cross listed with GSAS as BCMP 228. Classroom lectures on ...

Directors: J. . Walter

Prerequisites: Intended primarily for graduate students familiar with basic molecular biology or with strong biology/chemistry background.  Credits: 4 CREDITS (Non-Clinical Elective)

Offered: Fall.  Time: 9/9/2009- 12/14/2009; MWF; 10:30- 12:00 PM  Place: Bldg C, Cannon Rm

Description: An advanced treatment of molecular biology’s Central Dogma. Considers the molecular basis of information transfer from DNA to RNA to protein, using examples from eukaryotic and prokaryotic systems. Lectures, ...

Directors: W. W. Bender

Prerequisites: Prior exposure to molecular techniques and current residence in a lab equipped for molecular work.  Credits: 4 CREDITS (Non-Clinical Elective)

Offered: Not Offered 2009-2010  Time: TBA  Place: TBA

Description: Reviews principles of common lab techniques, discusses recent innovations. Topics: synthesis, separation and detection of nucleic acids and proteins, with traditional or high-throughput methods. Lectures, ...

Directors: P. . Sicinski

Prerequisites: General knowledge of biochemistry, molecular genetics and cell biology.  Credits: 4 CREDITS (Non-Clinical Elective)

Offered: Not Offered 2009-2010  Time: TBA  Place: TBA

Description: Examines the molecular basis of cancer including alterations in signal transduction, cell cycle, apoptosis and DNA repair with a focus on oncogenes, tumor suppressors, and oncogenic viruses. Explores the ...

Directors: A. B. Lassar

Prerequisites:   Credits: 4 CREDITS (Basic Science)

Offered: Spring.  Time: TBA  Place: TBA

Description: Analyzes the developmental programs of frog, chick, zebra fish and mouse embryos with emphasis on experimental strategies for understanding the responsible molecular mechanisms. Principal focus of the ...

Directors: M. R. Whitman

Prerequisites: Basic knowledge of biochemistry and genetics.  Credits: 4 CREDITS (Non-Clinical Elective)

Offered: Spring.  Time: TBA  Place: TBA

Description: Cellular and organismal metabolism, with focus on interrelationships between key metabolic pathways and human disease states. Genetic and acquired metabolic diseases and functional consequences for specific ...

Directors: D. L. Van Vactor

Prerequisites: General genetics and developmental biology courses recommended.  Credits: 4 CREDITS (Non-Clinical Elective)

Offered: Not Offered 2009-2010  Time: TBA  Place: TBA

Description: The course will emphasize the application of genetic tools for the analysis of fundamental developmental phenomena. We will provide an introduction to the biological principles and molecular mechanisms ...

Directors: L. A. Raftery

Prerequisites: Upper division Cell Biology or equivalent  Credits: 4 CREDITS (Non-Clinical Elective)

Offered: Fall  Time: 09/11/2009- 12/11/2009; F; 2:00-5:00 PM  Place: TMEC 448 and MGH Simches Research Center, Rm 3.310

Description: Explores developmental mechanisms through the life cycle, contrasting pluripotency and cell fate restriction in embryos and adult tissues. In depth analysis of in vivo approaches, with emphasis on tissue ...

Directors: F. M. Winston

Prerequisites: Intended for first-year graduate students.  Credits: 4 CREDITS (Non-Clinical Elective)

Offered: Fall.  Time: 09/09/2009-12/11/2009; MWF; 9:00-10:30 AM  Place: Bldg C, Cannon Rm

Description: An in-depth survey of genetics, beginning with basic principles and extending to modern approaches and special topics. We will draw on examples from various systems, such as Drosophila, C. elegans, mouse, ...

Directors: R. E. Kingston

Prerequisites: BCMP 200 and Genetics 201  Credits: 4 CREDITS (Non-Clinical Elective)

Offered: Spring  Time: TBA  Place: TBA

Description: Covers both biochemical and genetic studies in regulatory mechanisms. Small number of topics discussed in depth, using the primary literature. Topics range from prokaryotic transcription to eukaryotic ...

Directors: D. R. Beier

Credits: 4 CREDITS (Non-Clinical Elective)

Offered: Spring  Time: TBA  Place: TBA

Description: A literature discussion course on mammalian genetics, including mutation and disease cloning, mutagenesis, comparative genomics, cancer genetics, mammalian development, population genetics, complex trait ...

Directors: C. H. Newton-Cheh, S. A. Slaugenhaupt

Prerequisites: Genetics 201 or equivalent  Credits: 4 CREDITS (Non-Clinical Elective)

Offered: Fall  Time: 09/11/2009-12/11/2009; F; 2:00- 5:00 PM  Place: MGH Simches 3-3120

Description: Focus on translational medicine: the application of basic genetic discoveries to human disease. Will discuss specific genetic disorders and the approaches currently used to speed the transfer of knowledge ...

Directors: C. . Wu

Prerequisites: Introductory course in genetics and biology, or permission of the instructor.  Credits: 4 CREDITS (Non-Clinical Elective)

Offered: Spring  Time: TBA  Place: TBA

Description: Explores lesser known forms of gene regulation, including dosage compensation, imprinting, transvection, RIP, paramutation, methylation, and nuclear compartmentalization, taking examples from prokaryotes, ...

Directors: M. C. Carroll

Prerequisites: A background in genetics and biochemistry strongly recommended.  Credits: 4 CREDITS (Non-Clinical Elective)

Offered: Fall.  Time: 09/08/2009- 12/10/2009; TUTH; 1:30- 4:00 PM  Place: Modell Immunology Center, Fred Rosen Class. Rm 104

Description: As a comprehensive core course in immunology. Topics include a broad but intensive examination of the cells and molecules of the immune system. Special attention is given to the experimental approaches ...

Directors: S. J. Turley

Credits: 4 CREDITS (Non-Clinical Elective)

Offered: Spring  Time: TBA  Place: TBA

Description: Original research articles from fields including immunology, biochemistry, genetics, and cell and developmental biology will be critically analyzed in an intensive small group format. Grading will be based ...

Directors: D. B. Moody

Prerequisites: Course requirements: Immunol 201 or its equivalent  Credits: 4 CREDITS (Non-Clinical Elective)

Offered: Spring  Time: TBA  Place: TBA

Description: Continuation of Immunology 201 (IM702.0) as an intensive core course in fundamentals of the immune system. Emphasis on systems of immunity. Critical reading of primary literature. Offered jointly with ...

Directors: C. . Terhorst

Prerequisites: Course in basic Immunology.  Credits: 4 CREDITS (Non-Clinical Elective)

Offered: Spring  Time: TBA  Place: TBA

Description: This course discusses the mechanisms that underlie the pathogenesis of genetically determined primary immunodeficiencies and selected autoimmune diseases. Evaluates the use of animal models for study and ...

Directors: E. D. Kieff

Prerequisites:   Credits: 2 CREDITS (Basic Science)

Offered: Fall  Time: 09/09/2009- 12/09/2009; M 2:30- 4:00 PM & W 3:00- 5:00 PM  Place: Armenise Bldg., Room 330

Description: Introduction to virology. The lecture component reviews the basic principles of virology and introduces the major groups of animal viruses. Weekly discussion groups critically analyze selected papers from ...

Directors: J. R. Beckwith

Prerequisites: Some background in Genetics.  Credits: 4 CREDITS (Non-Clinical Elective)

Offered: Spring.  Time: TBA  Place: TBA

Description: Readings, discussion of social/ethical aspects of biology: history, philosophy of science; evolution vs. creationism; genetics and race; women and science; genetic testing; stem cell research; science ...

Directors: S. P. Whelan

Prerequisites: Graduate standing and permission required.  Credits: 4 CREDITS (Non-Clinical Elective)

Offered: Spring.  Time: TBA  Place: TBA

Description: Literature based reading. Proposal writing. Course covers a broad range of topics: viral genetics, structure/replication, pathogenesis, evolution ("emerging viruses"), chronic infection, latency, innate ...

Directors: M. R. Farzan

Prerequisites: General background in biochemistry and virology.  Credits: 4 CREDITS (Non-Clinical Elective)

Offered: Fall.  Time: 09/09/2009- 10/28/2009; W; 1:30- 4:30 PM  Place: TMEC Bldg Room L-007

Description: Students will write, present and evaluate research proposals in the areas of virus replication, viral pathogenesis and treatment and prevention of viral infections. Note: Offered jointly with GSAS as ...

Directors: S. . Lory

Credits: 4 CREDITS (Non-Clinical Elective)

Offered: Spring  Time: TBA  Place: TBA

Description: Devoted primarily to bacterial structure, physiology, genetics, regulatory mechanisms and pathogenesis. Class time consists of a combination of: 1) lecture, 2) presentations emphasizing methods, results ...

Directors: E. A. Kravitz

Prerequisites: Introductory neurobiology, biochemistry and genetics/ molecular biology are recommended.  Credits: 4 CREDITS (Non-Clinical Elective)

Offered: Spring  Time: TBA  Place: TBA

Description: Monday sessions involve patient presentations and "core" lectures describing clinical progression, pathology, and basic science underlying a major disease or disorder. Wednesdays, students present material ...

Directors: B. P. Bean

Prerequisites: Introductory Neurobiology.  Credits: 4 CREDITS (Non-Clinical Elective)

Offered: Fall.  Time: 09/08/2009- 12/10/2009; TUTH; 9:00 AM- 12:00 PM  Place: Goldenson Bldg Rm 122

Description: Introduction to the physiology of neurons. Topics include structure and function of ion channels, generation and propagation of action potentials, and physiology of synaptic transmission. Includes problem ...

Directors: C. J. Weitz

Prerequisites: Introductory Neurobiology, and molecular biology.  Credits: 4 CREDITS (Non-Clinical Elective)

Offered: Spring.  Time: TBA  Place: TBA

Description: Molecular biology and genetics of the nervous system. Emphasis on the importance of ligand-receptor interactions and receptor regulation for the function of the nervous system and on the mechanisms of ...

Directors: Q. . Ma

Prerequisites: Neurobiology 200 or permission of instructor.  Credits: 4 CREDITS (Non-Clinical Elective)

Offered: Spring.  Time: TBA  Place: TBA

Description: Lectures cover nervous system development, including neural induction, neural patterning, nerve cell type specification, nerve cell migration, neurotrophin and neuronal cell survival, axon guidance and ...

Directors: R. T. Born

Prerequisites: Neurobiology 220.  Credits: 4 CREDITS (Non-Clinical Elective)

Offered: Spring.  Time: TBA  Place: TBA

Description: Introduction to the physiology of circuits in the mammalian central nervous system. Topics include the auditory, somatosensory, olfactory, visual and oculomotor systems. Cross listed with GSAS as NBio ...

Directors: R. K. Jain

Prerequisites:   Credits: 1 CREDITS (Non-Clinical Elective)

Offered: Fall  Time: First Meeting 09/08/2009; M; 5:00- 7:00 PM  Place: MIT

Description: Tumor pathophysiology plays a central role in the growth, metastasis, detection, and treatment of solid tumors. Principles of transport phenomena are applied to develop a quantitative understanding of ...