HMS-Division Of Medical Sciences


BP715.0  Molecular Approaches to Drug Action, Discovery and Design
Directors: Coen, Donald Mark
Prerequisites: Primarily for graduate students.
Credits: 4.00 CREDITS (Non-Clinical Elective)
Offered: Spring.
Location: TBA
Time: TBA
Description: Application of molecular, systems, and structural biology, genetics, genomics, enzymology, and chemistry to drug action and development of new therapies. Analyzes molecular underpinnings of pharmacological principles. Examples...
BP715.0  Molecular Approaches to Drug Action, Discovery and Design
Directors: Coen, Donald Mark
Prerequisites: Primarily for graduate students.
Credits: 4.00 CREDITS (Non-Clinical Elective)
Offered: Spring.
Location: TBA
Time: TBA
Description: Application of molecular, systems, and structural biology, genetics, genomics, enzymology, and chemistry to drug action and development of new therapies. Analyzes molecular underpinnings of pharmacological principles. Examples...
BP719.0  Behavioral Pharmacology
Directors: Bergman, Jack; Kangas, Brian D
Credits: 4.00 CREDITS (Non-Clinical Elective)
Offered: Spring
Location: Sever 211
Time: 01/24/2017- 04/25/2017; TU; 2:00- 5:00 PM
Description: Introduction to CNS pharmacology and behavior in seminar format. Effects of psychomotor stimulants, antischizophrenics, opioid analgesics, and antianxiety agents on behavior. Emphasis on methodology and pharmacological analysis;...
BP722.0  Macromolecular NMR
Directors: Wagner, Gerhard
Credits: 4.00 CREDITS (Non-Clinical Elective)
Offered: Fall
Location: TBA
Time: TBA
Description: Theory and practice of modern methods of macromolecular structure determination using multi-dimensional NMR. Note: Given in alternate years. Cross listed with GSAS as BCMP 228. Classroom lectures on Mondays and Fridays. Wednesdays...
BP723.0  Molecular Biology
Directors: Heustis, Ronald Jason; Loparo, Joseph John
Prerequisites: Intended primarily for graduate students familiar with basic molecular biology or with strong biology/chemistry background.
Credits: 4.00 CREDITS (Non-Clinical Elective)
Offered: Fall.
Location: Cannon Room, Building C
Time: 09/02/2015- 12/11/2015; MWF; 10:45- 12:15 PM
Description: An advanced treatment of molecular biology’s Central Dogma. Considers the molecular basis of information transfer from DNA to RNA to protein, using examples from eukaryotic and prokaryotic systems. Lectures, discussion groups,...
CB704.0  Molecular and Systems Level Cancer Cell Biology
Directors: Sicinski, Peter
Prerequisites: General knowledge of biochemistry, molecular genetics, and cell biology.
Credits: 4.00 CREDITS (Non-Clinical Elective)
Offered: Spring
Location: TMEC-250
Time: 01/25/2016- 04/27/2016; MW; 1:00- 2:30 PM
Description: Examines the molecular and systems basis of cancer including alterations in signal transduction, cell cycle, apoptosis and DNA repair. Offered alternate years with Cell Biology 212. Cross listed with GSAS as Cell Biology 211.
CB704.0  Molecular and Systems Level Cancer Cell Biology
Directors: Sicinski, Peter
Prerequisites: General knowledge of biochemistry, molecular genetics, and cell biology.
Credits: 4.00 CREDITS (Non-Clinical Elective)
Offered: Spring
Location: TMEC-250
Time: 01/25/2016- 04/27/2016; MW; 1:00- 2:30 PM
Description: Examines the molecular and systems basis of cancer including alterations in signal transduction, cell cycle, apoptosis and DNA repair. Offered alternate years with Cell Biology 212. Cross listed with GSAS as Cell Biology 211.
CB710.0  Developmental Biology: Molecular Mechanisms of Vertebrate Development
Directors: Flanagan, John G; Lassar, Andrew B.
Credits: 4.00 CREDITS (Basic Science)
Offered: Spring.
Location: TMEC 448 January 23, 2017 only Conferences at TMEC 342 and TMEC 346
Time: 01/23/2017- 05/10/2017; MW; 2:00- 4:00 PM
Description: Analyzes the developmental programs of frog, chick, zebra fish and mouse embryos with emphasis on experimental strategies for understanding the responsible molecular mechanisms. Principal focus of the course is the establishment...
CB713.0  Molecular Biology of the Cell
Directors: Moazed, Danesh
Prerequisites: Basic knowledge of biochemistry and genetics.
Credits: 4.00 CREDITS (Non-Clinical Elective)
Offered: Spring.
Location: TBA
Time: TBA
Description: Cellular and organismal metabolism, with focus on interrelationships between key metabolic pathways and human disease states. Genetic and acquired metabolic diseases and functional consequences for specific organ systems. Lectures,...
CB721.0  Concepts in Development, Self-Renewal and Repair
Directors: Brack, Andrew Stephen; Drummond, Iain A.
Prerequisites: Upper division Cell Biology or equivalent
Credits: 4.00 CREDITS (Non-Clinical Elective)
Offered: Fall
Location: TMEC L-007
Time: 09/11/2015- 12/11/2015; FRI; 2:00- 5:00 PM
Description: Explores developmental mechanisms through the life cycle, contrasting pluripotency and cell fate restriction in embryos and adult tissues. In depth analysis of in vivo approaches, with emphasis on tissue repair and self-renewal....
CB721.0  Concepts in Development, Self-Renewal and Repair
Directors: Brack, Andrew Stephen; Drummond, Iain A.
Prerequisites: Upper division Cell Biology or equivalent
Credits: 4.00 CREDITS (Non-Clinical Elective)
Offered: Fall
Location: TMEC L-007
Time: 09/11/2015- 12/11/2015; FRI; 2:00- 5:00 PM
Description: Explores developmental mechanisms through the life cycle, contrasting pluripotency and cell fate restriction in embryos and adult tissues. In depth analysis of in vivo approaches, with emphasis on tissue repair and self-renewal....
GN701.0  Principles of Genetics
Directors: Winston, Fred Marshall
Prerequisites: Intended for first-year graduate students.
Credits: 4.00 CREDITS (Non-Clinical Elective)
Offered: Fall.
Location: Cannon Room, Building C
Time: 09/02/2015- 12/07/2015; MWF; 9:00- 10:20 AM
Description: An in-depth survey of genetics, beginning with basic principles and extending to modern approaches and special topics. We will draw on examples from various systems, such as Drosophila, C. elegans, mouse, human and bacteria. Note:...
GN703.0  Advanced Topics in Gene Expression
Directors: Buratowski, Stephen; Kingston, Robert Edward
Prerequisites: BCMP 200 and Genetics 201
Credits: 4.00 CREDITS (Non-Clinical Elective)
Offered: Spring
Location: TMEC 128
Time: 01/24/2017- 05/09/2017; TU; 2:00- 5:00 PM
Description: Covers both biochemical and genetic studies in regulatory mechanisms. Small number of topics discussed in depth, using the primary literature. Topics range from prokaryotic transcription to eukaryotic development. Cross listed...
GN711.0  Genetics in Medicine-From Bench to Bedside
Directors: Newton-Cheh, Christopher Holmes; Sweetser, David Alan
Prerequisites: Genetics 201 or equivalent
Credits: 4.00 CREDITS (Non-Clinical Elective)
Offered: Spring
Location: Simches Research Center, Room 3120, 185 Cambridge St., Boston, MA 02114
Time: 01/27/2017- 04/21/2017; FRI; 2:00- 5:00 PM
Description: Focus on translational medicine: the application of basic genetic discoveries to human disease. Will discuss specific genetic disorders and the approaches currently used to speed the transfer of knowledge from the laboratory...
GN711.0  Genetics in Medicine-From Bench to Bedside
Directors: Newton-Cheh, Christopher Holmes; Sweetser, David Alan
Prerequisites: Genetics 201 or equivalent
Credits: 4.00 CREDITS (Non-Clinical Elective)
Offered: Spring
Location: Simches Research Center, Room 3120, 185 Cambridge St., Boston, MA 02114
Time: 01/27/2017- 04/21/2017; FRI; 2:00- 5:00 PM
Description: Focus on translational medicine: the application of basic genetic discoveries to human disease. Will discuss specific genetic disorders and the approaches currently used to speed the transfer of knowledge from the laboratory...
GN724.0  Genotype to Phenotype: Epigenetics and Other Forms of Gene Regulation
Directors: Wu, Chao-ting
Prerequisites: Introductory course in genetics and biology, or permission of the instructor.
Credits: 4.00 CREDITS (Non-Clinical Elective)
Offered: Spring
Location: TBA
Time: TBA
Description: Explores lesser known forms of gene regulation, including dosage compensation, imprinting, transvection, RIP, paramutation, methylation, and nuclear compartmentalization, taking examples from prokaryotes, ciliates, fungi, plants,...
IM729.0  The Primary Immunodeficiencies
Directors: Terhorst, Cornelis
Prerequisites: Course in basic Immunology.
Credits: 4.00 CREDITS (Non-Clinical Elective)
Offered: Spring
Location: TBA
Time: TBA
Description: This course discusses the mechanisms that underlie the pathogenesis of genetically determined primary immunodeficiencies and selected autoimmune diseases. Evaluates the use of animal models for study and therapy of human disease...
MG705.0  Introduction to Virology
Directors: Nibert, Max L.
Credits: 2.00 CREDITS (Basic Science)
Offered: Fall
Location: NRB-833
Time: 09/02/2015- 12/9/2015; MON 9:00- 10:30 AM & WED 8:45- 10:30 AM
Description: Introduction to virology. The lecture component reviews the basic principles of virology and introduces the major groups of animal viruses. Weekly discussion groups critically analyze selected papers from the literature Note....
MG722.0  Social Issues in Biology
Directors: Beckwith, Jonathan Roger
Prerequisites: Some background in Genetics.
Credits: 4.00 CREDITS (Non-Clinical Elective)
Offered: Spring
Location: Room 2062 Biological Laboratories Cambridge Campus
Time: 01/26/2017- 04/27/2017; TH; 1:00- 4:00 PM
Description: Readings, discussion of social/ethical aspects of biology: history, philosophy of science; evolution vs. creationism; genetics and race; women and science; genetic testing; stem cell research; science journalism; genetics and...
MG723.0  Virology
Directors: Cunningham, James Morgan; Whelan, Sean P.J.
Prerequisites: Graduate standing and permission required.
Credits: 4.00 CREDITS (Non-Clinical Elective)
Offered: Spring.
Location: TMEC-426 (except Jan 23, 2017, in TMEC-328)
Time: 01/23/2017- 05/10/2017; MW; 2:30- 4:00 PM
Description: Literature based reading. Proposal writing. Course covers a broad range of topics: viral genetics, structure/replication, pathogenesis, evolution ("emerging viruses"), chronic infection, latency, innate and adaptive immunity,...
MG724.0  Proposal Writing
Directors: Gack, Michaela
Prerequisites: General background in biochemistry and virology.
Credits: 4.00 CREDITS (Non-Clinical Elective)
Offered: Fall.
Time: 8/30/2017- 11/1/2017; W; 1:45- 5:00 PM
Description: Students will write, present and evaluate research proposals in the areas of virus replication, viral pathogenesis and treatment and prevention of viral infections. Note: Offered jointly with GSAS as Virol 202.
NB713.0  Neurobiology of Disease
Directors: Kravitz, Edward Arthur
Prerequisites: Introductory neurobiology, biochemistry and genetics/ molecular biology are recommended.
Credits: 4.00 CREDITS (Non-Clinical Elective)
Offered: Spring
Location: Goldenson Building Room 122
Time: 01/25/2016- 04/27/2016; Mon 6:00-8:30 p.m. and Wed 7:00-9:30 p.m.
Description: Monday sessions involve patient presentations and "core" lectures describing clinical progression, pathology, and basic science underlying a major disease or disorder. Wednesdays, students present material from original literature...
NB713.0  Neurobiology of Disease
Directors: Kravitz, Edward Arthur
Prerequisites: Introductory neurobiology, biochemistry and genetics/ molecular biology are recommended.
Credits: 4.00 CREDITS (Non-Clinical Elective)
Offered: Spring
Location: Goldenson Building Room 122
Time: 01/25/2016- 04/27/2016; Mon 6:00-8:30 p.m. and Wed 7:00-9:30 p.m.
Description: Monday sessions involve patient presentations and "core" lectures describing clinical progression, pathology, and basic science underlying a major disease or disorder. Wednesdays, students present material from original literature...
NB714.0  Cellular Neurophysiology
Directors: Bean, Bruce Palmer
Prerequisites: Introductory Neurobiology.
Credits: 4.00 CREDITS (Non-Clinical Elective)
Offered: Fall.
Location: HMS Goldenson 122
Time: 09/08/2015-12/17/2015; TUTH; 9:00- 12:00 PM
Description: Introduction to the physiology of neurons. Topics include structure and function of ion channels, generation and propagation of action potentials, and physiology of synaptic transmission. Includes problem sets and reading of original...
NB715.0  Molecular Neurobiology
Directors: Datta, Sandeep Robert
Prerequisites: Introductory Neurobiology, and molecular biology.
Credits: 4.00 CREDITS (Non-Clinical Elective)
Offered: Spring.
Location: TBA
Time: TBA
Description: Molecular biology and genetics of the nervous system. Emphasis on the importance of ligand-receptor interactions and receptor regulation for the function of the nervous system and on the mechanisms of storage and release of neurotransmitters....
NB720.0  Molecular and Developmental Neurobiology
Directors: Goodrich, Lisa V.
Prerequisites: Neurobiology 200 or permission of instructor.
Credits: 4.00 CREDITS (Non-Clinical Elective)
Offered: Spring.
Location: TBA
Time: TBA
Description: Lectures cover nervous system development, including neural induction, neural patterning, nerve cell type specification, nerve cell migration, neurotrophin and neuronal cell survival, axon guidance and targeting, synaptogenesis...
NB721.0  Neurophysiology of Central Circuits
Directors: Born, Richard T.; Wilson, Rachel
Prerequisites: Neurobiology 220.
Credits: 4.00 CREDITS (Non-Clinical Elective)
Offered: Spring.
Location: Goldenson building, Room 229
Time: 01/27/2017- 04/25/2017; MW; 9:00 AM- 11:00 AM
Description: Introduction to the physiology of circuits in the mammalian central nervous system. Topics include the auditory, somatosensory, olfactory, visual and oculomotor systems. Cross listed with GSAS as NBio 204.
PA712.0  Tumor Pathophysiology and Transport Phenomena
Directors: Jain, Rakesh K.
Credits: 1.00 CREDITS (Non-Clinical Elective)
Offered: Fall
Location: MIT building E25-117
Time: 09/14/2015- 12/07/2015; MON. 5:00 -7:00 PM.
Description: Tumor pathophysiology plays a central role in the growth, metastasis, detection, and treatment of solid tumors. Principles of transport phenomena are applied to develop a quantitative understanding of tumor biology and treatment. Note:...
PA712.0  Tumor Pathophysiology and Transport Phenomena
Directors: Jain, Rakesh K.
Credits: 1.00 CREDITS (Non-Clinical Elective)
Offered: Fall
Location: MIT building E25-117
Time: 09/14/2015- 12/07/2015; MON. 5:00 -7:00 PM.
Description: Tumor pathophysiology plays a central role in the growth, metastasis, detection, and treatment of solid tumors. Principles of transport phenomena are applied to develop a quantitative understanding of tumor biology and treatment. Note:...
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