Directors: Coen, Donald Mark

Prerequisites: Primarily for graduate students.

Credits: 4.00 CREDITS (Non-Clinical Elective)

Offered: Spring.

Location: TBA

Time: TBA

Description: Application of molecular, systems, and structural biology, genetics, genomics, enzymology, and chemistry to drug action and development of new therapies. Analyzes molecular underpinnings of pharmacological principles. Examples...

Directors: Coen, Donald Mark

Prerequisites: Primarily for graduate students.

Credits: 4.00 CREDITS (Non-Clinical Elective)

Offered: Spring.

Location: TBA

Time: TBA

Description: Application of molecular, systems, and structural biology, genetics, genomics, enzymology, and chemistry to drug action and development of new therapies. Analyzes molecular underpinnings of pharmacological principles. Examples...

Directors: Bergman, Jack; Kangas, Brian D

Credits: 4.00 CREDITS (Non-Clinical Elective)

Offered: Spring

Location: Sever 211

Time: 01/24/2017- 04/25/2017; TU; 2:00- 5:00 PM

Description: Introduction to CNS pharmacology and behavior in seminar format. Effects of psychomotor stimulants, antischizophrenics, opioid analgesics, and antianxiety agents on behavior. Emphasis on methodology and pharmacological analysis;...

Directors: Wagner, Gerhard

Credits: 4.00 CREDITS (Non-Clinical Elective)

Offered: Fall

Location: TBA

Time: TBA

Description: Theory and practice of modern methods of macromolecular structure determination using multi-dimensional NMR. Note: Given in alternate years. Cross listed with GSAS as BCMP 228. Classroom lectures on Mondays and Fridays. Wednesdays...

Directors: Heustis, Ronald Jason; Loparo, Joseph John

Prerequisites: Intended primarily for graduate students familiar with basic molecular biology or with strong biology/chemistry background.

Credits: 4.00 CREDITS (Non-Clinical Elective)

Offered: Fall.

Location: Cannon Room, Building C

Time: 09/02/2015- 12/11/2015; MWF; 10:45- 12:15 PM

Description: An advanced treatment of molecular biology’s Central Dogma. Considers the molecular basis of information transfer from DNA to RNA to protein, using examples from eukaryotic and prokaryotic systems. Lectures, discussion groups,...

Directors: Sicinski, Peter

Prerequisites: General knowledge of biochemistry, molecular genetics, and cell biology.

Credits: 4.00 CREDITS (Non-Clinical Elective)

Offered: Spring

Location: TMEC-250

Time: 01/25/2016- 04/27/2016; MW; 1:00- 2:30 PM

Description: Examines the molecular and systems basis of cancer including alterations in signal transduction, cell cycle, apoptosis and DNA repair. Offered alternate years with Cell Biology 212. Cross listed with GSAS as Cell Biology 211.

Directors: Sicinski, Peter

Prerequisites: General knowledge of biochemistry, molecular genetics, and cell biology.

Credits: 4.00 CREDITS (Non-Clinical Elective)

Offered: Spring

Location: TMEC-250

Time: 01/25/2016- 04/27/2016; MW; 1:00- 2:30 PM

Description: Examines the molecular and systems basis of cancer including alterations in signal transduction, cell cycle, apoptosis and DNA repair. Offered alternate years with Cell Biology 212. Cross listed with GSAS as Cell Biology 211.

Directors: Flanagan, John G; Lassar, Andrew B.

Credits: 4.00 CREDITS (Basic Science)

Offered: Spring.

Location: TMEC 448 January 23, 2017 only Conferences at TMEC 342 and TMEC 346

Time: 01/23/2017- 05/10/2017; MW; 2:00- 4:00 PM

Description: Analyzes the developmental programs of frog, chick, zebra fish and mouse embryos with emphasis on experimental strategies for understanding the responsible molecular mechanisms. Principal focus of the course is the establishment...

Directors: Moazed, Danesh

Prerequisites: Basic knowledge of biochemistry and genetics.

Credits: 4.00 CREDITS (Non-Clinical Elective)

Offered: Spring.

Location: TBA

Time: TBA

Description: Cellular and organismal metabolism, with focus on interrelationships between key metabolic pathways and human disease states. Genetic and acquired metabolic diseases and functional consequences for specific organ systems. Lectures,...

Directors: Brack, Andrew Stephen; Drummond, Iain A.

Prerequisites: Upper division Cell Biology or equivalent

Credits: 4.00 CREDITS (Non-Clinical Elective)

Offered: Fall

Location: TMEC L-007

Time: 09/11/2015- 12/11/2015; FRI; 2:00- 5:00 PM

Description: Explores developmental mechanisms through the life cycle, contrasting pluripotency and cell fate restriction in embryos and adult tissues. In depth analysis of in vivo approaches, with emphasis on tissue repair and self-renewal....

Directors: Brack, Andrew Stephen; Drummond, Iain A.

Prerequisites: Upper division Cell Biology or equivalent

Credits: 4.00 CREDITS (Non-Clinical Elective)

Offered: Fall

Location: TMEC L-007

Time: 09/11/2015- 12/11/2015; FRI; 2:00- 5:00 PM

Description: Explores developmental mechanisms through the life cycle, contrasting pluripotency and cell fate restriction in embryos and adult tissues. In depth analysis of in vivo approaches, with emphasis on tissue repair and self-renewal....

Directors: Winston, Fred Marshall

Prerequisites: Intended for first-year graduate students.

Credits: 4.00 CREDITS (Non-Clinical Elective)

Offered: Fall.

Location: Cannon Room, Building C

Time: 09/02/2015- 12/07/2015; MWF; 9:00- 10:20 AM

Description: An in-depth survey of genetics, beginning with basic principles and extending to modern approaches and special topics. We will draw on examples from various systems, such as Drosophila, C. elegans, mouse, human and bacteria. Note:...

Directors: Buratowski, Stephen; Kingston, Robert Edward

Prerequisites: BCMP 200 and Genetics 201

Credits: 4.00 CREDITS (Non-Clinical Elective)

Offered: Spring

Location: TMEC 128

Time: 01/24/2017- 05/09/2017; TU; 2:00- 5:00 PM

Description: Covers both biochemical and genetic studies in regulatory mechanisms. Small number of topics discussed in depth, using the primary literature. Topics range from prokaryotic transcription to eukaryotic development. Cross listed...

Directors: Newton-Cheh, Christopher Holmes; Sweetser, David Alan

Prerequisites: Genetics 201 or equivalent

Credits: 4.00 CREDITS (Non-Clinical Elective)

Offered: Spring

Location: Simches Research Center, Room 3120, 185 Cambridge St., Boston, MA 02114

Time: 01/27/2017- 04/21/2017; FRI; 2:00- 5:00 PM

Description: Focus on translational medicine: the application of basic genetic discoveries to human disease. Will discuss specific genetic disorders and the approaches currently used to speed the transfer of knowledge from the laboratory...

Directors: Newton-Cheh, Christopher Holmes; Sweetser, David Alan

Prerequisites: Genetics 201 or equivalent

Credits: 4.00 CREDITS (Non-Clinical Elective)

Offered: Spring

Location: Simches Research Center, Room 3120, 185 Cambridge St., Boston, MA 02114

Time: 01/27/2017- 04/21/2017; FRI; 2:00- 5:00 PM

Description: Focus on translational medicine: the application of basic genetic discoveries to human disease. Will discuss specific genetic disorders and the approaches currently used to speed the transfer of knowledge from the laboratory...

Directors: Wu, Chao-ting

Prerequisites: Introductory course in genetics and biology, or permission of the instructor.

Credits: 4.00 CREDITS (Non-Clinical Elective)

Offered: Spring

Location: TBA

Time: TBA

Description: Explores lesser known forms of gene regulation, including dosage compensation, imprinting, transvection, RIP, paramutation, methylation, and nuclear compartmentalization, taking examples from prokaryotes, ciliates, fungi, plants,...

Directors: Mempel, Thorsten Roman; von Andrian, Ulrich H.

Prerequisites: A background in genetics and biochemistry strongly recommended.

Credits: 4.00 CREDITS (Non-Clinical Elective)

Offered: Fall

Location: Modell Immunology Center, Fred S. Rosen Lecture Hall, Room 100A

Time: 9/2/2015- 12/21/2015; TUTH; 1:30-3:00 PM, with section TUTH, 3:00-4:00 PM

Description: As a comprehensive core course in immunology. Topics include a broad but intensive examination of the cells and molecules of the immune system. Special attention is given to the experimental approaches that led to the general...

Directors: Mempel, Thorsten Roman; von Andrian, Ulrich H.

Prerequisites: A background in genetics and biochemistry strongly recommended.

Credits: 4.00 CREDITS (Non-Clinical Elective)

Offered: Fall

Location: Modell Immunology Center, Fred S. Rosen Lecture Hall, Room 100A

Time: 9/2/2015- 12/21/2015; TUTH; 1:30-3:00 PM, with section TUTH, 3:00-4:00 PM

Description: As a comprehensive core course in immunology. Topics include a broad but intensive examination of the cells and molecules of the immune system. Special attention is given to the experimental approaches that led to the general...

Directors: Wesemann, Duane R

Credits: 4.00 CREDITS (Non-Clinical Elective)

Offered: Spring

Location: Jeffrey Modell Immunology Center; 100A

Time: 01/23/2017- 04/26/2017; TH; 10:00 AM- 1:00 PM

Description: Original research articles from fields including immunology, biochemistry, genetics, and cell and developmental biology will be critically analyzed in an intensive small group format. Grading will be based on class participation,...

Directors: Pittet, Mikael J.; Swirski, Filip K.

Prerequisites: Course requirements: Immunol 201 or its equivalent

Credits: 4.00 CREDITS (Non-Clinical Elective)

Offered: Spring

Location: Modell Center 100A Rosen Lecture Hall

Time: 1/24/2017- 5/4/2017; Tuesdays and Thursdays 1:30 - 4:00 p.m.

Description: Continuation of Immunology 201 (IM702.0) with emphasis on innate and inflammatory diseases. Critical reading of primary literature. Offered jointly with GSS as Immun 202.

Directors: Pittet, Mikael J.; Swirski, Filip K.

Prerequisites: Course requirements: Immunol 201 or its equivalent

Credits: 4.00 CREDITS (Non-Clinical Elective)

Offered: Spring

Location: Modell Center 100A Rosen Lecture Hall

Time: 1/24/2017- 5/4/2017; Tuesdays and Thursdays 1:30 - 4:00 p.m.

Description: Continuation of Immunology 201 (IM702.0) with emphasis on innate and inflammatory diseases. Critical reading of primary literature. Offered jointly with GSS as Immun 202.

Directors: Terhorst, Cornelis

Prerequisites: Course in basic Immunology.

Credits: 4.00 CREDITS (Non-Clinical Elective)

Offered: Spring

Location: TBA

Time: TBA

Description: This course discusses the mechanisms that underlie the pathogenesis of genetically determined primary immunodeficiencies and selected autoimmune diseases. Evaluates the use of animal models for study and therapy of human disease...

Directors: Nibert, Max L.

Credits: 2.00 CREDITS (Basic Science)

Offered: Fall

Location: NRB-833

Time: 09/02/2015- 12/9/2015; MON 9:00- 10:30 AM & WED 8:45- 10:30 AM

Description: Introduction to virology. The lecture component reviews the basic principles of virology and introduces the major groups of animal viruses. Weekly discussion groups critically analyze selected papers from the literature Note....

Directors: Beckwith, Jonathan Roger

Prerequisites: Some background in Genetics.

Credits: 4.00 CREDITS (Non-Clinical Elective)

Offered: Spring

Location: Room 2062 Biological Laboratories Cambridge Campus

Time: 01/26/2017- 04/27/2017; TH; 1:00- 4:00 PM

Description: Readings, discussion of social/ethical aspects of biology: history, philosophy of science; evolution vs. creationism; genetics and race; women and science; genetic testing; stem cell research; science journalism; genetics and...

Directors: Cunningham, James Morgan; Whelan, Sean P.J.

Prerequisites: Graduate standing and permission required.

Credits: 4.00 CREDITS (Non-Clinical Elective)

Offered: Spring.

Location: TMEC-426 (except Jan 23, 2017, in TMEC-328)

Time: 01/23/2017- 05/10/2017; MW; 2:30- 4:00 PM

Description: Literature based reading. Proposal writing. Course covers a broad range of topics: viral genetics, structure/replication, pathogenesis, evolution ("emerging viruses"), chronic infection, latency, innate and adaptive immunity,...

Directors: Gack, Michaela

Prerequisites: General background in biochemistry and virology.

Credits: 4.00 CREDITS (Non-Clinical Elective)

Offered: Fall.

Location: TMEC 212

Time: 09/02/2015- 11/11/2015; W; 1:45- 5:00 PM

Description: Students will write, present and evaluate research proposals in the areas of virus replication, viral pathogenesis and treatment and prevention of viral infections. Note: Offered jointly with GSAS as Virol 202.

Directors: Kravitz, Edward Arthur

Prerequisites: Introductory neurobiology, biochemistry and genetics/ molecular biology are recommended.

Credits: 4.00 CREDITS (Non-Clinical Elective)

Offered: Spring

Location: Goldenson Building Room 122

Time: 01/25/2016- 04/27/2016; Mon 6:00-8:30 p.m. and Wed 7:00-9:30 p.m.

Description: Monday sessions involve patient presentations and "core" lectures describing clinical progression, pathology, and basic science underlying a major disease or disorder. Wednesdays, students present material from original literature...

Directors: Kravitz, Edward Arthur

Prerequisites: Introductory neurobiology, biochemistry and genetics/ molecular biology are recommended.

Credits: 4.00 CREDITS (Non-Clinical Elective)

Offered: Spring

Location: Goldenson Building Room 122

Time: 01/25/2016- 04/27/2016; Mon 6:00-8:30 p.m. and Wed 7:00-9:30 p.m.

Description: Monday sessions involve patient presentations and "core" lectures describing clinical progression, pathology, and basic science underlying a major disease or disorder. Wednesdays, students present material from original literature...

Directors: Bean, Bruce Palmer

Prerequisites: Introductory Neurobiology.

Credits: 4.00 CREDITS (Non-Clinical Elective)

Offered: Fall.

Location: HMS Goldenson 122

Time: 09/08/2015-12/17/2015; TUTH; 9:00- 12:00 PM

Description: Introduction to the physiology of neurons. Topics include structure and function of ion channels, generation and propagation of action potentials, and physiology of synaptic transmission. Includes problem sets and reading of original...

Directors: Datta, Sandeep Robert

Prerequisites: Introductory Neurobiology, and molecular biology.

Credits: 4.00 CREDITS (Non-Clinical Elective)

Offered: Spring.

Location: TBA

Time: TBA

Description: Molecular biology and genetics of the nervous system. Emphasis on the importance of ligand-receptor interactions and receptor regulation for the function of the nervous system and on the mechanisms of storage and release of neurotransmitters....

Directors: Goodrich, Lisa V.

Prerequisites: Neurobiology 200 or permission of instructor.

Credits: 4.00 CREDITS (Non-Clinical Elective)

Offered: Spring.

Location: TBA

Time: TBA

Description: Lectures cover nervous system development, including neural induction, neural patterning, nerve cell type specification, nerve cell migration, neurotrophin and neuronal cell survival, axon guidance and targeting, synaptogenesis...

Directors: Born, Richard T.; Wilson, Rachel

Prerequisites: Neurobiology 220.

Credits: 4.00 CREDITS (Non-Clinical Elective)

Offered: Spring.

Location: Goldenson building, Room 229

Time: 01/27/2017- 04/25/2017; MW; 9:00 AM- 11:00 AM

Description: Introduction to the physiology of circuits in the mammalian central nervous system. Topics include the auditory, somatosensory, olfactory, visual and oculomotor systems. Cross listed with GSAS as NBio 204.

Directors: Jain, Rakesh K.

Credits: 1.00 CREDITS (Non-Clinical Elective)

Offered: Fall

Location: MIT building E25-117

Time: 09/14/2015- 12/07/2015; MON. 5:00 -7:00 PM.

Description: Tumor pathophysiology plays a central role in the growth, metastasis, detection, and treatment of solid tumors. Principles of transport phenomena are applied to develop a quantitative understanding of tumor biology and treatment. Note:...

Directors: Jain, Rakesh K.

Credits: 1.00 CREDITS (Non-Clinical Elective)

Offered: Fall

Location: MIT building E25-117

Time: 09/14/2015- 12/07/2015; MON. 5:00 -7:00 PM.

Description: Tumor pathophysiology plays a central role in the growth, metastasis, detection, and treatment of solid tumors. Principles of transport phenomena are applied to develop a quantitative understanding of tumor biology and treatment. Note:...